Difference between revisions of "Scientific Figures"

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=== How to interpret scientific epidemiology reports? ===
 
=== How to interpret scientific epidemiology reports? ===
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{| style="width: 190px; height: 100px; float:right; padding:4px; border-collapse:collapse" border="1"
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|-
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| style="background:#D2DFEE; text-align:center" |'''Hypothesis'''
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| style="text-align:center;padding:4px"|An original assumption that must be demonstrated or rejected through experimentation.
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The reliability of any empirical evidence, scientific or not, depends on having met three basic benchmarks: 
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*An assurance of identity, namely that what is being measured is indeed what is claimed to be measured, and measured with sufficient accuracy.
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*An assurance of the absence of other explanations, namely that the effects observed are due exclusively to what is being measured (exposure to PS, in our case), and not to other disturbances that interfere with the observations and may alter and confound the results.
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*An assurance of consistency, namely that  results are consistently reproduced by different reports.
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Without meeting these three guarantees, no hypothesis can aspire to reach any degree of credible evidence, and cannot be credibly taken as the basis for reasoned policy decisions, either public or private.
  
 
<blockquote>"In epidemiologic research, [increases in risk of less than 100 percent] are considered small and are usually difficult to interpret. Such increases may be due to chance, statistical bias, or the effects of confounding factors that are sometimes not evident". Source: National Cancer Institute, Press Release, October 26, 1994</blockquote>
 
<blockquote>"In epidemiologic research, [increases in risk of less than 100 percent] are considered small and are usually difficult to interpret. Such increases may be due to chance, statistical bias, or the effects of confounding factors that are sometimes not evident". Source: National Cancer Institute, Press Release, October 26, 1994</blockquote>

Revision as of 22:12, 12 June 2012

Interpreting scientific figures

Epidemiologic studies of passive smoke (ETS) – not the same as science

The epidemiology of ETS claims correlations of ETS exposure with cancer, cardiovascular, and other diseases that are not caused by single entities such as viruses or bacteria, but depend on a constellation of possible causes, none either necessary or sufficient. Laboratory and clinical studies have proven unable to determine specific causal mechanism for such diseases. In this regard, Doll and Peto, arguably the most prominent epidemiologists today, have concluded that:

[E]pidemiological observations...have serious disadvantages... [T]hey can seldom be made according to the strict requirements of experimental science and therefore may be open to a variety of interpretations. A particular factor may be associated with some disease merely because of its association with some other factor that causes the disease, or the association may be an artefact due to some systematic bias in the information collection……..
[I]t is commonly, but mistakenly, supposed that multiple regression, logistic regression, or various forms of standardization can routinely be used to answer the question: “Is the correlation of exposure (E) with disease (D) due merely to a common correlation of both with some con¬founding factor (or factors)?”
... Moreover, it is obvious that multiple regressions cannot correct for important variables that have not been recorded at all.”…….[T]hese disadvantages limit the value of observations in humans, but...until we know exactly how cancer is caused and how some factors are able to modify the effects of others, the need to observe imaginatively what actually hap¬pens to various different categories of people will remain.” *
* (Doll R, Peto R, The causes of cancer, JNCI 66:1192-1312, 1981. p. 1281)

(The “multiple regression” and “logical regression” referred to in the quotes above are techniques used in the statistics of epidemiology.)

Thus, while epidemiologists insist that their discipline is a science, clearly it is not a mainstream experimental science that produces reliable causal connections that could justify public and private policies.

Study types in epidemiology

Epidemiologic risks in general are estimated from observing differences in the frequency with which diseases appear (incidence) among groups more or less exposed to whatever agent the researchers are studying. Various types of studies are used in epidemiology, but only two have been used in the case of PS. Let’s briefly examine how these studies are conducted, and what they actually measure.

Retrospective cohort (or longitudinal) studies

These studies record different individual recalls of disease incidence in groups of people possibly exposed to PS to varying degrees during the previous course of their lifetimes. In such studies, risk is estimated from differences of incidence in relation to differences in PS exposure. Only a handful of such studies have been performed in regard to PS.

Case-control studies

These constitute by far the majority of PS studies. They record different individual recalls of possible lifetime PS exposure in two groups of people. One of these groups is composed exclusively of subjects all having the disease under study (lung cancer, for instance): this group is called the cases. The other is composed of subjects who are all free of the disease under study: this group is called the controls.
In case-control studies the incidence is 0% in the controls and 100% in the cases. Therefore, a key understanding is that in such studies risks are conjectured as differentials of exposure recall, and not actually estimated as differentials of disease incidence. Increased risk is inferred but not directly estimated if exposure is found to be higher among cases, and protection is inferred but not directly estimated if exposure is found to be higher among controls.

Please note that the term “individual recall” means the recollections of individual people concerning the phenomenon that the researchers are interested in. In other words, researchers in these studies use people’s memories as to guess the actual amount of second-hand smoke that they were exposed to, and the comparison of the case and control groups is based on this recollection. Obviously, this fact alone is a considerable “wild card” when it comes to the reliability of the basic data upon which the study depends.

Relative Risk/Odds Ratio

The arithmetic of risk calculation is the same for cohort and case-control studies, except for a difference in terminology. In cohort studies the ratio used for risk calculation is called RR (relative risk), while in case control studies the ratio is called OR (odds ratio).

However, the important difference is that the cohort studies estimate risk directly as differentials of disease incidence, since cohort studies observe only the health outcomes that could be associated with exposure to a particular factor. The case-control studies only assume risk from differentials of exposure, since they are designed to observe the exposure that subjects may have had in the past to the factor of interest.

Let us go into a bit more detail as to how the calculations are done – but don’t worry, it is simple arithmetic!

In cohort studies, risk is measured as a difference in disease incidence between exposed and non-exposed subjects. The risk is defined as relative risk (RR), and it is expressed this way: RR.png

Thus, the disease incidence rate in the exposed subjects is simply divided by the incidence rate in non-exposed subjects. The RR ratio reflects that a certain incidence of disease is observed in both non-exposed and exposed subjects, due to multiple background causes operating in conjunction with, or entirely separate from the exposure under study. Therefore, risk in the exposed is said to be an increment or decrement of incidence, relative to the basic incidence of the non-exposed subjects.

In the RR ratio above, if the rates are the same in exposed and non-exposed subjects, the RR=1 and therefore there is no risk differential. If RR is greater than 1, the risk is said to be increased in the exposed subjects. If RR is smaller than 1, the risk is said to be decreased in the exposed subjects, indicating that the exposure under study might be possibly protective.

Because case-control studies infer but do not directly estimate possible risk, their results are expressed as odds ratios (OR), namely the ratio between the odds (expressed as % or other rate) of being exposed for the cases and the controls:

OR.png

In the above ratio, if the odds are the same in exposed and non-exposed subjects, the OR=1 and there is no inference of difference in risk. If OR is greater than 1, there is an inference of increased risk in the cases. If OR is smaller than 1, there is an inference of decreased risk for the cases, presuming that the exposure may possibly protect for the disease under study.

Both cohort and case-control studies are affected by similar difficulties of design, data collection, and interpretation — difficulties that are far worse for case-control studies that uniquely rely on vague recollections of exposure.

How to interpret scientific epidemiology reports?

Hypothesis
An original assumption that must be demonstrated or rejected through experimentation.

The reliability of any empirical evidence, scientific or not, depends on having met three basic benchmarks:

  • An assurance of identity, namely that what is being measured is indeed what is claimed to be measured, and measured with sufficient accuracy.
  • An assurance of the absence of other explanations, namely that the effects observed are due exclusively to what is being measured (exposure to PS, in our case), and not to other disturbances that interfere with the observations and may alter and confound the results.
  • An assurance of consistency, namely that results are consistently reproduced by different reports.

Without meeting these three guarantees, no hypothesis can aspire to reach any degree of credible evidence, and cannot be credibly taken as the basis for reasoned policy decisions, either public or private.

"In epidemiologic research, [increases in risk of less than 100 percent] are considered small and are usually difficult to interpret. Such increases may be due to chance, statistical bias, or the effects of confounding factors that are sometimes not evident". Source: National Cancer Institute, Press Release, October 26, 1994

"As a general rule of thumb, we are looking for a relative risk of 3 or more before accepting a paper for publication." - Marcia Angell, editor of the New England Journal of Medicine

"My basic rule is if the relative risk isn't at least 3 or 4, forget it." - Robert Temple, director of drug evaluation at the Food and Drug Administration.

"An association is generally considered weak if the odds ratio [relative risk] is under 3.0 and particularly when it is under 2.0, as is the case in the relationship of ETS and lung cancer." - Dr. Kabat, IAQC epidemiologist